Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201555 | 0.94 | CTSB (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5121516 | 0.90 | CTSB (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3869800 | 0.87 | PSEN1 (0.53) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3869797 | 0.87 | PSEN1 (0.53) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5209020 | 0.87 | PSEN1 (0.53) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3877669 | 0.87 | PSEN1 (0.58) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3877670 | 0.87 | PSEN1 (0.58) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5446725 | 0.87 | PSEN1 (0.58) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8365430 | 0.86 | BACE1 (0.47) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4799325 | 0.83 | PSEN1 (0.52) | BACE1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096942-A1 | Substituted Hydroxyethylamines | ELAN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7312360-B2 | Substituted hydroxyethylamines | ELAN PHARMACEUTICALS, INC. (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2003050073-A1 | SUBSTITUTED HYDROXYETHYLAMINES | ELAN PHARMACEUTICALS, INC. (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096942-A1 | Substituted Hydroxyethylamines | BACE1, BACE2, MME | BACE1 1/4885PSEN1 8/4885PSEN2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.