Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931617 | 0.94 | KLK5 (0.59) | KLK5SYKTRPM8CTSDPSEN1 | |
| SCHEMBL16824022 | 0.90 | SYK (0.61) | KLK5SYKCTSKATMCTRB1 | |
| SCHEMBL16824023 | 0.90 | SYK (0.61) | KLK5SYKCTSKATMCTRB1 | |
| SCHEMBL18143207 | 0.90 | SYK (0.61) | KLK5SYKCTSKATMCTRB1 | |
| SCHEMBL19812740 | 0.90 | SYK (0.61) | KLK5SYKCTSKATMCTRB1 | |
| SCHEMBL6449655 | 0.87 | CTSD (0.66) | KLK5TRPM8CTSDPSEN1PSEN2 | |
| SCHEMBL6444857 | 0.87 | KLK5 (0.63) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8534875 | 0.87 | KLK5 (0.63) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6445261 | 0.87 | KLK5 (0.63) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6445320 | 0.87 | KLK5 (0.63) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006013-A1 | DIAMINEDIOLS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-01-23 | — | — | WO | disclosed |