Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 13/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.51 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.50 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377406 | 0.85 | MAP2K4 (0.66) | FLT3MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL8251977 | 0.85 | MAP2K4 (0.55) | MAPK1MAP2K4MAPKAPK3MAPK6CSNK1D | |
| SCHEMBL12073055 | 0.75 | CSNK1D (0.51) | MAPK1MAP2K4MAPKAPK3MAPK6CSNK1D | |
| SCHEMBL5379122 | 0.74 | LRRK2 (0.54) | FLT3MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL2861089 | 0.74 | ROCK2 (0.54) | MAPK1MAP2K4MAPKAPK3MAPK6ROCK2 | |
| SCHEMBL5377540 | 0.73 | MAPK1 (0.54) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL2567664 | 0.72 | GAA (0.66) | — | |
| SCHEMBL19965569 | 0.72 | MAP2K4 (0.47) | FLT3MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL6320721 | 0.72 | MAPK1 (0.60) | FLT3MAPK1CSNK1DABL1BCR | |
| SCHEMBL30147526 | 0.72 | CCNC (0.50) | FLT3CSNK1DTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |