SCHEMBL8366125

SCHEMBL8366125

Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)nc4)c3Cl)c2n1

nearest known ligand 0.88

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8366131 1.00 BDKRB2 (0.88) BDKRB2
SCHEMBL8367942 0.93 BDKRB2 (1.00) BDKRB2
SCHEMBL8367940 0.93 BDKRB2 (1.00) BDKRB2
SCHEMBL7747169 0.90 BDKRB2 (0.81) BDKRB2
SCHEMBL7747164 0.90 BDKRB2 (0.81) BDKRB2
SCHEMBL8804365 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL9094302 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL6665953 0.90 BDKRB2 (0.89) BDKRB2
SCHEMBL6665949 0.90 BDKRB2 (0.89) BDKRB2
SCHEMBL8366130 0.90 BDKRB2 (0.84) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed