Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630020 | 0.88 | OPRD1 (0.57) | OPRD1OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL56293 | 0.75 | OPRD1 (0.58) | OPRD1OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13690026 | 0.75 | MEN1 (0.58) | OPRD1OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3099492 | 0.75 | OPRD1 (0.48) | OPRD1OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21581202 | 0.75 | OPRD1 (0.63) | OPRD1OPRK1OPRM1MAPT | |
| SCHEMBL2899076 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAMEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL18742622 | 0.74 | OPRD1 (0.57) | OPRD1OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7556949 | 0.74 | CHRM4 (0.61) | OPRD1OPRK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1709936 | 0.74 | MEN1 (0.59) | OPRD1OPRK1ALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL541133 | 0.74 | MEN1 (0.63) | OPRD1OPRK1ALDH1A1SMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965580-A | TREATMENT OF SUBSTANCE P- AND NEUROKININ-DEPENDENT DISORDERS | SANOFI (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5939411-A | PIPERIDINE DERIVATIVES SUBSTITUTED AT POSITION 4 WITH NEW FUNCTIONS OTHER THAN THOSE DESCRIBED PREVIOUSLY HAVE A HIGH AFFINITY FOR NEUROKININ RECEPTORS AND ARE USEFUL FOR TREATMENT OF SUBSTANCE P AND NEUROKININ DEPENDENT PATHOLOGIES | SANOFI (FR) | 1999-08-17 | — | — | US | disclosed |
| US-5830906-A | Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them | SANOFI (FR) | 1998-11-03 | — | — | US | disclosed |