Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.89 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.63 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | INSR | P06213 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366002 | 0.94 | EGFR (1.00) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL6954806 | 0.84 | EGFR (0.78) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL14090716 | 0.84 | EGFR (0.79) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL8361665 | 0.82 | EGFR (0.87) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL14264605 | 0.82 | EGFR (0.90) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL8366047 | 0.81 | ERBB2 (0.90) | EGFRERBB2 | |
| SCHEMBL2748246 | 0.81 | EGFR (0.68) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL8368189 | 0.80 | EGFR (0.87) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL4003900 | 0.79 | EGFR (0.72) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL4178252 | 0.79 | EGFR (0.65) | EGFRERBB2MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |