SCHEMBL8367362

SCHEMBL8367362

CSc1ncccc1C(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1

nearest known ligand 0.79

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8367363 1.00 BDKRB2 (0.79) BDKRB2
SCHEMBL8364443 0.93 BDKRB2 (0.82) BDKRB2
SCHEMBL8364441 0.93 BDKRB2 (0.82) BDKRB2
SCHEMBL8366109 0.92 BDKRB2 (0.83) BDKRB2
SCHEMBL8366112 0.92 BDKRB2 (0.83) BDKRB2
SCHEMBL8364178 0.90 BDKRB2 (0.85) BDKRB2
SCHEMBL8364181 0.90 BDKRB2 (0.85) BDKRB2
SCHEMBL8364133 0.89 BDKRB2 (0.87) BDKRB2
SCHEMBL8364135 0.89 BDKRB2 (0.87) BDKRB2
SCHEMBL8364905 0.89 BDKRB2 (0.88) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed