Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366151 | 0.89 | HRH1 (0.70) | HRH1CYP2D6USP2POLBKCNH2 | |
| SCHEMBL4653613 | 0.84 | HRH1 (0.63) | HRH1CYP2D6USP2POLBTACR2 | |
| SCHEMBL28268965 | 0.80 | HRH1 (0.60) | HRH1CYP2D6USP2POLBKCNH2 | |
| SCHEMBL21359686 | 0.79 | HRH1 (0.71) | HRH1CYP2D6USP2POLBKCNH2 | |
| SCHEMBL18884476 | 0.78 | HRH1 (0.70) | HRH1CYP2D6KCNH2 | |
| SCHEMBL8367704 | 0.76 | HRH1 (0.69) | HRH1CYP2D6TACR2TACR1KCNH2 | |
| SCHEMBL28422607 | 0.75 | HRH1 (0.71) | HRH1CYP2D6KCNH2 | |
| SCHEMBL18884525 | 0.75 | HRH1 (0.68) | HRH1CYP2D6USP2POLBTACR2 | |
| Bilastine SCHEMBL29402994 | 0.73 | HRH1 (0.82) | HRH1CYP2D6USP2POLBKCNH2 | |
| Bilastine SCHEMBL991810 | 0.73 | HRH1 (0.82) | HRH1CYP2D6USP2POLBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877187-A | Benzimidazole derivatives with antihistaminic activity | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (FAES) (ES) | 1999-03-02 | — | — | US | disclosed |