SCHEMBL8368455

SCHEMBL8368455

CNC(=O)C(=NOC)c1ccccc1COc1nc(Cl)ccc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.44
MRGPRX4 Q96LA9 2/20 0.34
SGMS2 Q8NHU3 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
PTK2 Q05397 2/20 0.33
CTSV O60911 1/20 0.33
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
CNR2 P34972 2/20 0.32
JAK2 O60674 1/20 0.32
NTRK1 P04629 1/20 0.32
TYK2 P29597 1/20 0.32
KDR P35968 1/20 0.32
JAK3 P52333 1/20 0.32
PTK2B Q14289 1/20 0.32
NTRK3 Q16288 1/20 0.32
NTRK2 Q16620 1/20 0.32
PTGES O14684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8368453 1.00 HIF1A (0.44) HIF1AMRGPRX4SGMS2MAOAMAOB
SCHEMBL8370584 0.89 HIF1A (0.44) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8370581 0.89 HIF1A (0.44) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8368448 0.87 HIF1A (0.43) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8368450 0.87 HIF1A (0.43) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8372658 0.85 HIF1A (0.42) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8372656 0.85 HIF1A (0.42) HIF1ASGMS2MAOAMAOBPTK2
SCHEMBL8370616 0.85 HIF1A (0.46) HIF1ASGMS2MAOAMAOB
SCHEMBL8370620 0.85 HIF1A (0.46) HIF1ASGMS2MAOAMAOB
SCHEMBL8368530 0.85 HIF1A (0.45) HIF1AMRGPRX4SGMS2PTK2JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617011-B1 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO (JP) 1999-01-20 EP disclosed
US-5506358-A USEFUL AS AGRICULTURAL FUNGICIDES SHIONOGI & CO., LTD. (JP) 1996-04-09 US disclosed
EP-0617011-A2 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO., LTD. (JP) 1994-09-28 EP disclosed