Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 17/20 | 0.51 |
| ▸ | FNTB | P49356 | 17/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936956 | 0.88 | FNTA (0.50) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| SCHEMBL6776418 | 0.87 | FNTA (0.51) | FNTAFNTB | |
| SCHEMBL8367831 | 0.83 | L3MBTL1 (0.48) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8995686 | 0.80 | FNTA (0.58) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| SCHEMBL8995687 | 0.80 | FNTA (0.58) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| Hydrochloric Acid SCHEMBL8995669 | 0.79 | FNTA (0.57) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| Hydrochloric Acid SCHEMBL8995668 | 0.79 | FNTA (0.57) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| SCHEMBL8937043 | 0.76 | FNTA (0.62) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| Hydrochloric Acid SCHEMBL8936951 | 0.75 | FNTA (0.61) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 | |
| SCHEMBL8937027 | 0.75 | L3MBTL1 (0.48) | FNTAFNTBPGGT1BL3MBTL1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817630-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0817630-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5578629-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5534537-A | Prodrugs of inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1996-07-09 | — | — | US | disclosed |