Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369404 | 1.00 | PNMT (0.61) | PNMTSIGMAR1TAAR1SLC18A2SLC6A4 | |
| SCHEMBL11445930 | 0.83 | PNMT (0.65) | PNMTSIGMAR1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL4716937 | 0.81 | TMEM97 (0.57) | PNMTSIGMAR1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL5018935 | 0.79 | PNMT (0.70) | PNMTSIGMAR1TAAR1SLC6A4CYP2D6 | |
| SCHEMBL178533 | 0.78 | TAAR1 (0.63) | SIGMAR1TAAR1SLC18A2SLC6A4CYP2D6 | |
| SCHEMBL21286088 | 0.78 | TAAR1 (0.63) | SIGMAR1TAAR1SLC18A2SLC6A4CYP2D6 | |
| SCHEMBL7316113 | 0.78 | TAAR1 (0.63) | SIGMAR1TAAR1SLC18A2SLC6A4CYP2D6 | |
| SCHEMBL10989200 | 0.77 | TAAR1 (0.47) | SIGMAR1TAAR1SLC18A2SLC6A4CYP2D6 | |
| SCHEMBL10599864 | 0.77 | PNMT (0.51) | PNMTSIGMAR1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL4907481 | 0.76 | PNMT (0.65) | PNMTSIGMAR1TAAR1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999064861-A2 | METHOD OF IDENTIFYING ANTIDEPRESSANT COMPOUNDS | UNIVERSITY COLLEGE LONDON (GB) | 1999-12-16 | — | — | WO | claimed |
| WO-1999064861-A2 | METHOD OF IDENTIFYING ANTIDEPRESSANT COMPOUNDS | UNIVERSITY COLLEGE LONDON (GB) | 1999-12-16 | — | — | WO | disclosed |