SCHEMBL8370301

SCHEMBL8370301

O=P(N(c1ccccc1)c1ccccc1)(N(c1ccccc1)c1ccccc1)N(c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.59
KMT2A Q03164 3/20 0.59
MEN1 O00255 2/20 0.59
ALDH1A1 P00352 6/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ALOX15 P16050 1/20 0.42
KCNA5 P22460 1/20 0.41
L3MBTL1 Q9Y468 4/20 0.40
TDP1 Q9NUW8 3/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CA2 P00918 1/20 0.38
CA4 P22748 1/20 0.38
CA5A P35218 1/20 0.38
ATM Q13315 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2309806 0.78 MEN1 (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL27651298 0.78 HTT (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL96680 0.78 HTT (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL8530739 0.78 MEN1 (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL7526246 0.78 HTT (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL18889454 0.78 HTT (0.54) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL7528709 0.78 HTT (0.48) HTTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL12150822 0.76 HTT (0.46) HTTKMT2AMEN1ALDH1A1NPSR1
Hydrochloric Acid SCHEMBL27416015 0.76 HTT (0.46) HTTKMT2AMEN1ALDH1A1NPSR1
Hydrochloric Acid SCHEMBL27627985 0.76 MEN1 (0.46) HTTKMT2AMEN1ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601609-B1 Inhibiting coke-formation with phosphoric triamide NALCO CHEMICAL CO (US) 1999-01-27 EP disclosed
US-5360531-A Corrosion resistance; by-product inhibition; heat exchangers NALCO CHEMICAL COMPANY (US) 1994-11-01 US disclosed
EP-0601609-A1 Phosphoric triamide coking inhibitors NALCO CHEMICAL COMPANY (US) 1994-06-15 EP disclosed
US-4085268-A Disubstituted s-triazines ARMSTRONG CORK COMPANY (US) 1978-04-18 US disclosed