SCHEMBL8370647

SCHEMBL8370647

CC1=C(C)C(C)C([Si](Cl)(c2ccccc2)c2ccccc2)=C1C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10320693 0.81 ESR1 (0.32) ESR1ESR2
SCHEMBL6899721 0.79 ESR1 (0.44) ESR1ESR2
SCHEMBL10320464 0.79 ESR1 (0.35) ESR1ESR2
SCHEMBL8216331 0.76 ESR1 (0.31) ESR1ESR2
SCHEMBL12814912 0.75
SCHEMBL10320207 0.75 LMNA (0.33) ESR1ESR2
SCHEMBL10317521 0.75 ESR1 (0.32) ESR1ESR2
SCHEMBL12814800 0.75
SCHEMBL12817199 0.75 LMNA (0.33) ESR1ESR2
SCHEMBL12815655 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617044-B1 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI CHEMICALS INC (JP) 1999-01-20 EP disclosed
US-5360921-A REACTING LITHIUM, SODIUM OR POTASSIUM SALT OF A CYCLOPENTADIENE DERIVATIVE WITH A SILICON OR GERMANIUM HALIDE COMPOUND IN THE PRESENCE OF A CYANIDE OR A THIOCYANATE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-01 US disclosed
EP-0617044-A2 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-09-28 EP disclosed