⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906814 | 1.00 | — | — | |
| SCHEMBL6282205 | 1.00 | — | — | |
| SCHEMBL11442823 | 0.79 | KDM4E (0.70) | — | |
| SCHEMBL11442824 | 0.79 | KDM4E (0.70) | — | |
| SCHEMBL11442822 | 0.79 | KDM4E (0.70) | — | |
| SCHEMBL30499040 | 0.79 | KDM4E (0.70) | — | |
| SCHEMBL1703735 | 0.79 | — | — | |
| SCHEMBL1703734 | 0.79 | — | — | |
| SCHEMBL648808 | 0.78 | — | — | |
| SCHEMBL8372870 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240002313-A1 | [11C]-LABELED ACYCLIC RETINOID, CENTRAL NERVOUS SYSTEM ACTIVATOR, AND PRODUCTION METHODS FOR SAME | NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (JP) | 2024-01-04 | — | — | US | disclosed |
| CN-117098749-A | [11C] Labeled acyclic retinoids, central nervous system activators and methods for their manufacture | 国立研究开发法人国立长寿医疗研究中心 | 2023-11-21 | — | — | CN | disclosed |
| EP-4249058-A1 | [11C]-LABELLED ACYCLIC RETINOID, CENTRAL NERVOUS SYSTEM ACTIVATOR, AND PRODUCTION METHODS FOR SAME | National Center for Geriatrics and Gerontology (JP) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022107865-A1 | [11C]-LABELLED ACYCLIC RETINOID, CENTRAL NERVOUS SYSTEM ACTIVATOR, AND PRODUCTION METHODS FOR SAME | 国立研究開発法人国立長寿医療研究センター | 2022-05-27 | — | — | WO | disclosed |
| EP-3981766-A1 | INDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Eisai R&D Management Co., Ltd. (JP) | 2022-04-13 | — | — | EP | disclosed |
| CN-113024466-A | Tetra-substituted olefin compound and use thereof | 卫材 R&D 管理有限公司 | 2021-06-25 | — | — | CN | disclosed |
| CN-107847498-B | Tetra-substituted olefin compound and use thereof | 卫材R&D管理有限公司 | 2021-04-13 | — | — | CN | disclosed |
| US-10919835-B2 | Compounds and synthetic methods for the preparation of retinoid X receptor-specific retinoids | Io Therapeutics, Inc. (US) | 2021-02-16 | — | — | US | disclosed |
| US-10851065-B2 | Tetrasubstituted alkene compounds and their use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-12-01 | — | — | US | disclosed |
| US-20200190008-A1 | COMPOUNDS AND SYNTHETIC METHODS FOR THE PREPARATION OF RETINOID X RECEPTOR-SPECIFIC RETINOIDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-06-18 | — | — | US | disclosed |
| WO-2016196337-A1 | TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-12-08 | — | — | WO | disclosed |
| US-20160347717-A1 | TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-12-01 | — | — | US | disclosed |
| WO-2013059898-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING SESQUITERPENE LACTONES BELONGING TO THE CLASS OF FURAN HELIANGOLIDES FOR THE TREATMENT OF PARASITIC INFECTIONS AND TUMOURS | UNIVERSIDADE FEDERAL DE OURO PRETO - UFOP (BR) | 2013-05-02 | — | — | WO | disclosed |
| EP-0673911-B1 | Process for producing optically active carboxylic acids and chiral ligands for this purpose | TAKASAGO PERFUMERY CO LTD (JP) | 1999-01-20 | — | — | EP | disclosed |
| US-5563295-A | HYDROGENATION OF OLEFINIC CARBOXYLIC ACID USING RUTHENIUM-PHOSPHINE COMPLEX CATALYST | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1996-10-08 | — | — | US | disclosed |
| EP-0673911-A1 | Process for producing optically active carboxylic acids and chiral ligands for this purpose | Takasago International Corporation (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-4975454-A | Triene compounds having a chromene structure | ADIR ET COMPAGNIE (FR) | 1990-12-04 | — | — | US | disclosed |
| US-4097496-A | ANTIPROSTAGLANDIN ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-27 | — | — | US | disclosed |
| US-4083990-A | ANTIPROSTAGLANDIN EFFECT | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-11 | — | — | US | disclosed |
| US-3984459-A | ANTI-PROSTAGLANDINS | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-10-05 | — | — | US | disclosed |