Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.58 |
| ▸ | CACNA1I | Q9P0X4 | 11/20 | 0.58 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430776 | 0.93 | KCNH2 (0.67) | KCNH2CACNA1ICACNA1HCYP2D6HTR4 | |
| SCHEMBL4276555 | 0.89 | KCNH2 (0.60) | KCNH2CACNA1ICACNA1HCYP2D6HTR4 | |
| SCHEMBL8373973 | 0.89 | CACNA1I (0.60) | KCNH2CACNA1ICACNA1HCYP2D6CCR2 | |
| SCHEMBL4273384 | 0.89 | CACNA1I (0.59) | KCNH2CACNA1ICACNA1HCYP2D6CCR2 | |
| SCHEMBL4272213 | 0.89 | KCNH2 (0.59) | KCNH2CACNA1ICACNA1HCYP2D6HTR4 | |
| SCHEMBL8372955 | 0.88 | KCNH2 (0.58) | KCNH2CACNA1ICACNA1HCYP2D6CCR2 | |
| SCHEMBL15353997 | 0.88 | KCNH2 (0.55) | KCNH2CACNA1ICACNA1HCYP2D6 | |
| SCHEMBL15353979 | 0.88 | CACNA1I (0.46) | KCNH2CACNA1ICACNA1HCYP2D6HTR4 | |
| SCHEMBL4273172 | 0.87 | KCNH2 (0.57) | KCNH2CACNA1ICACNA1HCYP2D6HTR4 | |
| SCHEMBL8370966 | 0.87 | KCNH2 (0.56) | KCNH2CACNA1ICACNA1HCYP2D6CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096522-B2 | N-piperidinyl acetamide derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20140011996-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2014-01-09 | — | — | US | disclosed |
| US-20090298883-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MARK G. DEGIACOMO, CHAPTER 7 TRUSTEE OF EPIRUS BIOPHARMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011996-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1H, CACNA1B | KCNH2 60/4885CACNA1I 4/4885CACNA1H 2/4885 |
| US-20090298883-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1H, CACNA1B | KCNH2 60/4885CACNA1I 4/4885CACNA1H 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.