SCHEMBL8373384

SCHEMBL8373384

Oc1ccc(C2CC(c3ccccc3)=NN2c2ccccc2)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 9/20 0.82
MEN1 O00255 5/20 0.82
KMT2A Q03164 5/20 0.82
GAA P10253 3/20 0.82
HSP90AA1 P07900 2/20 0.82
EGFR P00533 1/20 0.66
ERBB2 P04626 1/20 0.66
CA1 P00915 2/20 0.65
CA2 P00918 2/20 0.65
CA12 O43570 1/20 0.65
CA9 Q16790 1/20 0.65
L3MBTL1 Q9Y468 2/20 0.64
ATM Q13315 2/20 0.61
MAOB P27338 1/20 0.61
NR3C2 P08235 1/20 0.61
PDE5A O76074 1/20 0.58
KDM4E B2RXH2 2/20 0.58
ALDH1A1 P00352 2/20 0.58
GLA P06280 2/20 0.58
HTT P42858 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23962450 0.97 MEN1 (0.82) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL8179557 0.94 MEN1 (0.82) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL13680425 0.92 EGFR (0.75) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL9628765 0.90 PRKCZ (0.77) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL9628590 0.90 PRKCZ (1.00) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL27955200 0.90 MEN1 (0.77) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL27955194 0.90 MEN1 (1.00) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL27955202 0.90 MEN1 (0.77) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL27955197 0.90 PRKCZ (0.90) PRKCZMEN1KMT2AGAAHSP90AA1
SCHEMBL13680429 0.89 EGFR (0.71) PRKCZMEN1KMT2AGAAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112707863-A Acrylate-substituted pyrazoline derivative, photocuring composition and preparation method 同济大学 2021-04-27 CN disclosed
WO-1999065961-A1 HOLE INJECTOR POLYMERS THOMSON-CSF (FR) 1999-12-23 WO disclosed
US-5095029-A FUNGICIDAL 1,3,5-TRIARYL-2-PYRAZOLINES BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0212450-B1 SOLID SCINTILLATOR COUNTING COMPOSITIONS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-12-27 EP disclosed
US-4692266-A FOR USE IN LIQUIDS, FLUOR PARTICLES IN BINDER, POROSITY EASTMAN KODAK COMPANY (US) 1987-09-08 US disclosed
EP-0212450-A1 Solid scintillator counting compositions EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-03-04 EP disclosed
US-4127499-A POLYMERIC PARTICLES, HYDROPHOBIC FLUOR EASTMAN KODAK COMPANY (US) 1978-11-28 US disclosed