Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.58 |
| ▸ | KDM6B | O15054 | 7/20 | 0.58 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376698 | 0.89 | KDM4C (0.43) | KDM4CKDM6BP2RX4KDM4EALDH1A1 | |
| SCHEMBL8375139 | 0.85 | KDM4C (0.57) | KDM4CKDM6BECE1MUS81LATS1 | |
| SCHEMBL8374734 | 0.84 | KDM4C (0.58) | KDM4CKDM6BLATS1HCAR3P2RX4 | |
| Hydrochloric Acid SCHEMBL8375849 | 0.84 | KDM4C (0.55) | KDM4CKDM6BECE1MUS81LATS1 | |
| SCHEMBL8376730 | 0.83 | KDM4C (0.56) | KDM4CKDM6BKDM4ELMNAHPGD | |
| SCHEMBL8376711 | 0.82 | HSD17B10 (0.42) | KDM4CKDM6BP2RX4KDM4EALDH1A1 | |
| SCHEMBL8375851 | 0.76 | KDM4C (0.59) | KDM4CKDM6BLATS1HCAR3ALDH1A1 | |
| SCHEMBL8375133 | 0.76 | CYP17A1 (0.41) | KDM4CKDM6BIDO1KDM4E | |
| SCHEMBL8375140 | 0.76 | KDM6B (0.51) | KDM4CKDM6BECE1MUS81LATS1 | |
| SCHEMBL8375145 | 0.76 | LMNA (0.44) | KDM4CKDM6BP2RX4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821239-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE CAUSED BY CHOLINERGIC DEFICIT | FROMMER LAWRENCE & HUAG LLP (US) | 1998-10-13 | — | — | US | claimed |
| US-5869480-A | ALLEVIATING MEMORY DYSFUNCTION CHARACTERIZED BY CHOLINERGIC DEFICIT | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5866565-A | ALZHEIMER'S DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5821239-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE CAUSED BY CHOLINERGIC DEFICIT | FROMMER LAWRENCE & HUAG LLP (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |