Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328593 | 0.85 | GBA1 (0.63) | ACP1L3MBTL1SMN1; SMN2GBA1EGFR | |
| SCHEMBL3122164 | 0.82 | EGFR (0.51) | ACP1L3MBTL1GBA1EGFRPDGFRB | |
| SCHEMBL30960992 | 0.82 | EGFR (0.51) | ACP1L3MBTL1GBA1EGFRPDGFRB | |
| SCHEMBL24649607 | 0.81 | ACP1 (0.66) | ACP1L3MBTL1SMN1; SMN2TP53EGFR | |
| SCHEMBL1084629 | 0.80 | EGFR (0.59) | SMN1; SMN2GBA1TP53EGFRPDGFRB | |
| SCHEMBL8381530 | 0.80 | ACP1 (0.42) | ACP1L3MBTL1GAAALDH1A1HTT | |
| SCHEMBL3973470 | 0.80 | POLB (0.44) | ACP1L3MBTL1HTTKDM4ELMNA | |
| SCHEMBL30013919 | 0.79 | EGFR (0.54) | GBA1EGFRPDGFRBKDRALDH1A1 | |
| SCHEMBL23577358 | 0.79 | EGFR (0.54) | GBA1EGFRPDGFRBKDRALDH1A1 | |
| SCHEMBL1083853 | 0.79 | ACP1 (0.67) | ACP1L3MBTL1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874438-A | A DRUG TREATING BRAIN DISORDERS, DISEASES OF CENTRAL NERVOUS SYSTEM, DEMENTIA, DEPRESSION, MYOTONIC DYSTROPHY, ASTHMA | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-23 | — | — | US | disclosed |
| US-5739127-A | 2,4'-bridged bis-2,4-diaminoquinazolines | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-14 | — | — | US | disclosed |
| US-4048312-A | 2,4-Diaminoquinazolines as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |
| US-3962264-A | AMMONIA, TETRA-ALKOXY-PROPANE, MALONONITRILE | PFIZER INC. (US) | 1976-06-08 | — | — | US | disclosed |
| US-3956495-A | 2,4-Diaminoquinazolines as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1976-05-11 | — | — | US | disclosed |
| US-3950160-A | INHIBITING THE GROWTH OF WEEDS WITH 2-SUBSTITUTED PYRDIDOPYIMIDINES AND SALTS THEREOF | PFIZER INC. (US) | 1976-04-13 | — | — | US | disclosed |