Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375458 | 0.85 | ACP1 (0.64) | GBA1EGFRPDGFRBKDRACP1 | |
| SCHEMBL1084629 | 0.82 | EGFR (0.59) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL17800052 | 0.81 | GBA1 (0.58) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL9430149 | 0.81 | MAT2A (0.51) | GBA1CYP1A2PRMT5MAT2AKDM4E | |
| SCHEMBL3122164 | 0.81 | EGFR (0.51) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL30960992 | 0.81 | EGFR (0.51) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL13413604 | 0.79 | GAA (0.59) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL18354103 | 0.78 | GBA1 (1.00) | GBA1EGFRPDGFRBKDRALDH1A1 | |
| SCHEMBL3110618 | 0.78 | EGFR (0.76) | GBA1EGFRPDGFRBKDRPDE5A | |
| SCHEMBL29909096 | 0.78 | EGFR (0.76) | GBA1EGFRPDGFRBKDRPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535104-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1996-09-04 | — | — | EP | disclosed |
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| US-5276028-A | Psychological disorders, anticonvulsants, anxiolytic or hypnotics and cognition activators | NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0535104-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000298-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-09 | — | — | WO | disclosed |