Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | GALK1 | P51570 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423016 | 0.87 | PTGS2 (0.51) | SMN1; SMN2DHODHPTGS2EPHX2MEN1 | |
| SCHEMBL8375470 | 0.85 | DHODH (0.49) | SMN1; SMN2DHODHEPHX2MEN1KMT2A | |
| SCHEMBL8375473 | 0.84 | PTGS2 (0.65) | SMN1; SMN2DHODHPTGS2EPHX2MEN1 | |
| SCHEMBL8376535 | 0.84 | CRACR2A (0.40) | SMN1; SMN2PTGS2NPC1TSHRKDR | |
| SCHEMBL8375479 | 0.83 | NPC1 (0.45) | SMN1; SMN2DHODHNPC1TRPV1RAB9A | |
| SCHEMBL9429300 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2PTGS2EPHX2FLT1KDR | |
| SCHEMBL8376590 | 0.78 | FLT1 (0.48) | SMN1; SMN2NPC1TSHRFLT1KDR | |
| SCHEMBL9423117 | 0.76 | HTT (0.52) | SMN1; SMN2PTGS2NPC1FLT1KDR | |
| SCHEMBL9429179 | 0.75 | PTGS2 (0.65) | SMN1; SMN2DHODHPTGS2EPHX2MEN1 | |
| SCHEMBL9423064 | 0.75 | MAPT (0.58) | SMN1; SMN2DHODHNPC1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573318-B1 | 4-Phenylcarbamoyl-3-isoxazolecarboxylic acid derivatives with antiinflammatory activity | HOECHST MARION ROUSSEL INC (FR) | 1999-03-24 | — | — | EP | disclosed |
| EP-0573318-A1 | Phenyl carboxamide isoxazole derivatives and salts, process for their preparation and the new intermediates thereof. Their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1993-12-08 | — | — | EP | disclosed |