Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.32 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376486 | 0.93 | PTGS1 (0.38) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8377323 | 0.91 | PTGS1 (0.37) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8376588 | 0.90 | PTGS1 (0.48) | PTGS1ALDH1A1PPARDIP6K1IP6K2 | |
| SCHEMBL8378828 | 0.89 | PTGS1 (0.38) | PTGS1KDM4EPPARDIP6K1IP6K2 | |
| SCHEMBL8375523 | 0.85 | HRH3 (0.33) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8375562 | 0.84 | PTGS1 (0.31) | PTGS1IP6K1IP6K2 | |
| SCHEMBL8380071 | 0.84 | TRPV1 (0.32) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8377362 | 0.84 | MEN1 (0.39) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8380040 | 0.84 | MEN1 (0.32) | PTGS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8378864 | 0.84 | S1PR1 (0.32) | PTGS1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |