Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375523 | 0.88 | HRH3 (0.33) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL8378864 | 0.87 | S1PR1 (0.32) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL8380071 | 0.87 | TRPV1 (0.32) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL8377404 | 0.87 | PTPN1 (0.30) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL8380040 | 0.87 | MEN1 (0.32) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL8376537 | 0.86 | PPARG (0.30) | — | |
| SCHEMBL8375562 | 0.85 | PTGS1 (0.31) | PTGS1 | |
| SCHEMBL8375766 | 0.85 | TSHR (0.31) | — | |
| SCHEMBL8376486 | 0.85 | PTGS1 (0.38) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL8377381 | 0.84 | PPARA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |