SCHEMBL8375813

SCHEMBL8375813

CC(C)(C)OC(=O)NCCOc1cc(-c2ccc(C(F)(F)F)cc2)on1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.45
TRPV1 Q8NER1 2/20 0.43
HDAC1 Q13547 6/20 0.42
HDAC6 Q9UBN7 5/20 0.42
HDAC3 O15379 4/20 0.42
HDAC10 Q969S8 3/20 0.42
HDAC2 Q92769 3/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
BCHE P06276 1/20 0.42
CNR2 P34972 1/20 0.42
PDK2 Q15119 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8376903 0.89 TP53 (0.47) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8375551 0.88 HDAC1 (0.44) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8379534 0.88 TP53 (0.47) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8375557 0.87 BCHE (0.47) FAAHHDAC1HDAC6HDAC3HDAC10
SCHEMBL8378887 0.87 CA12 (0.45) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8375763 0.87 IDO1 (0.44) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8378941 0.87 GABRA5 (0.46) FAAHHDAC1HDAC6HDAC3HDAC10
SCHEMBL8380141 0.86 NPC1 (0.51) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8374992 0.85 HDAC1 (0.42) HDAC1HDAC6HDAC3HDAC10HDAC2
SCHEMBL8378768 0.84 BCHE (0.45) HDAC1HDAC6HDAC3HDAC10HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6005116-A HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA SANKYO COMPANY, LIMITED (JP) 1999-12-21 US disclosed
EP-0885891-A1 ISOXAZOLE DERIVATIVES SANKYO COMPANY LIMITED (JP) 1998-12-23 EP disclosed