Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371587 | 0.89 | CYP1A2 (0.39) | PARP1MAPTHPGDALDH1A1KDM4E | |
| SCHEMBL8372835 | 0.87 | ALDH1A1 (0.39) | MAPTMEN1KMT2AMAPK8ALDH1A1 | |
| SCHEMBL8374844 | 0.86 | PARP1 (0.40) | PARP1SIRT2AURKARPS6KB1MAPT | |
| SCHEMBL8373611 | 0.86 | PARP1 (0.40) | PARP1SIRT2AURKARPS6KB1CD38 | |
| SCHEMBL8375961 | 0.84 | KDM5B (0.38) | PARP1SIRT2AURKARPS6KB1MAPK8 | |
| SCHEMBL8371575 | 0.84 | PARP1 (0.36) | PARP1ALDH1A1KDM4ETSHRBRS3 | |
| SCHEMBL8371603 | 0.84 | PARP1 (0.43) | PARP1SIRT2AURKARPS6KB1CD38 | |
| SCHEMBL8371551 | 0.83 | BTK (0.37) | PARP1AURKARPS6KB1MAPK8GAA | |
| SCHEMBL8372849 | 0.81 | BTK (0.45) | PARP1CD38ALDH1A1KDM4EGAA | |
| SCHEMBL8372827 | 0.80 | PARP1 (0.40) | PARP1SIRT2CD38MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | claimed |