Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.80 |
| ▸ | MEN1 | O00255 | 13/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.74 |
| ▸ | HTT | P42858 | 3/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | PPARG | P37231 | 1/20 | 0.72 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.72 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837865 | 0.92 | MAPT (0.73) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL4512505 | 0.89 | MEN1 (1.00) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL837699 | 0.86 | MEN1 (0.82) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL838276 | 0.82 | MEN1 (0.59) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL13125792 | 0.81 | CFTR (1.00) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL23270901 | 0.81 | MAPT (0.98) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL22703718 | 0.80 | MAPT (0.75) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL4531290 | 0.78 | PIK3CG (1.00) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL4534326 | 0.78 | MEN1 (0.83) | MAPTMEN1KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL4512539 | 0.78 | MEN1 (0.83) | MAPTMEN1KMT2ASMN1; SMN2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143295-B2 | Compounds having activity in correcting mutant-CFTR processing and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-27 | — | — | US | disclosed |
| US-20080318984-A1 | Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318984-A1 | Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof | CFTR, ABCC5, QPCT | MAPT 4358/4885MEN1 4634/4885KMT2A 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.