Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 16/20 | 0.59 |
| ▸ | MAPT | P10636 | 16/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 16/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837705 | 0.82 | MAPT (0.80) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL13993032 | 0.80 | KMT2A (0.47) | MEN1MAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20463932 | 0.75 | MEN1 (0.71) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL837865 | 0.75 | MAPT (0.73) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL14109874 | 0.73 | LMNA (0.47) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL15688998 | 0.71 | MEN1 (0.87) | MEN1MAPTKMT2AALDH1A1GAA | |
| SCHEMBL4512505 | 0.71 | MEN1 (1.00) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL837699 | 0.70 | MEN1 (0.82) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7144160 | 0.70 | MAPT (0.53) | MEN1MAPTKMT2AALDH1A1GAA | |
| SCHEMBL5774803 | 0.69 | MEN1 (1.00) | MEN1MAPTKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143295-B2 | Compounds having activity in correcting mutant-CFTR processing and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-27 | — | — | US | disclosed |