Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377412 | 0.92 | TSHR (0.31) | TSHR | |
| SCHEMBL8375766 | 0.92 | TSHR (0.31) | TSHR | |
| SCHEMBL8378822 | 0.90 | RECQL (0.30) | — | |
| SCHEMBL8375523 | 0.84 | HRH3 (0.33) | ALDH1A1PTGS1MAPTLPAR1LPAR3 | |
| SCHEMBL8378845 | 0.84 | S1PR1 (0.32) | — | |
| SCHEMBL8375562 | 0.84 | PTGS1 (0.31) | TRPV1PTGS1 | |
| SCHEMBL8376486 | 0.84 | PTGS1 (0.38) | ALDH1A1MAPK1HPGDPTGS1SMN1; SMN2 | |
| SCHEMBL8380071 | 0.83 | TRPV1 (0.32) | ALDH1A1TRPV1PTGS1 | |
| SCHEMBL8377362 | 0.83 | MEN1 (0.39) | ALDH1A1PTGS1 | |
| SCHEMBL8380040 | 0.83 | MEN1 (0.32) | ALDH1A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |