Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901230 | 1.00 | PPARG (0.48) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL28732572 | 1.00 | PPARG (0.48) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL11724981 | 1.00 | PPARG (0.48) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL11339313 | 1.00 | PPARG (0.48) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL3905545 | 1.00 | PPARG (0.48) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL29170081 | 0.98 | PPARG (0.47) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL7379765 | 0.98 | PPARG (0.46) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL6313224 | 0.93 | TSHR (0.46) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL30594196 | 0.89 | PPARG (0.43) | PPARGPPARAKMT2AKDM4EL3MBTL1 | |
| SCHEMBL2734713 | 0.88 | ALDH1A1 (0.47) | KMT2ATSHRALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |