Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 9/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377704 | 1.00 | PRKAA2 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL8882143 | 0.92 | ITGB3 (0.49) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL7284061 | 0.88 | ITGB3 (0.55) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL8378204 | 0.88 | ITGB3 (0.55) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL7274759 | 0.86 | ITGB3 (0.68) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL7293550 | 0.86 | ITGB3 (0.68) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL8382121 | 0.84 | ITGB3 (0.58) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL8692892 | 0.80 | PRKAA2 (0.42) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL7283671 | 0.79 | ITGB3 (0.67) | ITGB3ITGA2BCYP51A1 | |
| SCHEMBL8377721 | 0.79 | ITGB3 (0.67) | ITGB3ITGA2BCYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5658928-A | ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS | HOFFMANN-LA ROCHE INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5545658-A | FOR TREATMENT OR PROPHYLAXIS OF ILLNESSES WHICH ARE CAUSED BY THE BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELETS AND BY BLOOD PLATELET AGGREGATION AND CELL-CELL ADHESION | HOFFMAN-LA ROCHE INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5378712-A | Antithrombosis | Hoffmann-La Roche Inc (US) | 1995-01-03 | — | — | US | disclosed |