Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101973 | 0.65 | — | — | |
| SCHEMBL728996 | 0.63 | TOP2A (0.50) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL9139881 | 0.59 | TOP2A (0.41) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL4788784 | 0.59 | TOP2A (0.41) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL16349791 | 0.59 | TOP2A (0.52) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL4788789 | 0.59 | TOP2A (0.41) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| Icrf-193 SCHEMBL14006976 | 0.59 | TOP2A (1.00) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL9752550 | 0.59 | TOP2A (0.47) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL17716288 | 0.59 | TOP2A (0.46) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL15548784 | 0.59 | TOP2A (0.47) | TOP2ATOP2BALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866570-A | Treatment of vascular leakage and related syndrome such as septic shock by administration of metalloproteinase inhibitors | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0642353-A1 | TREATMENT OF VASCULAR LEAKAGE SYNDROME AND COLLAGENASE INDUCED DISEASE BY ADMINISTRATION OF MATRIX METALLOPROTEINASE INHIBITORS | ONCOLOGIX, INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993023075-A1 | TREATMENT OF VASCULAR LEAKAGE SYNDROME AND COLLAGENASE INDUCED DISEASE BY ADMINISTRATION OF MATRIX METALLOPROTEINASE INHIBITORS | ONCOLOGIX, INC. (US) | 1993-11-25 | — | — | WO | disclosed |