SCHEMBL8378906

SCHEMBL8378906

O=C(O)CCCCOc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.62
MEN1 O00255 1/20 0.61
TTR P02766 1/20 0.61
PPOX P50336 1/20 0.61
KMT2A Q03164 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
MRGPRX4 Q96LA9 12/20 0.51
PPARA Q07869 2/20 0.48
PPARD Q03181 2/20 0.48
PPARG P37231 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8874528 0.94 FFAR1 (0.64) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL8378639 0.88 MEN1 (0.64) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL8380185 0.83 MEN1 (0.62) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL11243867 0.82 MEN1 (0.72) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL6290662 0.82 MEN1 (0.72) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL9796493 0.82 MEN1 (0.68) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL11116540 0.80 MEN1 (0.69) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL10661473 0.80 MEN1 (0.69) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL8378139 0.80 MEN1 (0.69) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL10665077 0.80 MEN1 (0.65) FFAR1MEN1TTRPPOXKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0716073-B1 Process for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted) benzene compounds AMERICAN CYANAMID CO (US) 1999-03-31 EP disclosed
US-5596124-A FOR USE WITH CEREAL CROPS AMERICAN CYANAMID COMPANY (US) 1997-01-21 US disclosed
EP-0716073-A1 Process for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted) benzene compounds American Cyanamid Company (US) 1996-06-12 EP disclosed