Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8379648 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8379733 | 0.88 | TRPA1 (0.52) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8379726 | 0.88 | TRPA1 (0.52) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8382114 | 0.85 | EPHX2 (0.43) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8379189 | 0.85 | EPHX2 (0.43) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8379053 | 0.85 | NR1H4 (0.58) | SMN1; SMN2EPHX2NR1H4MAPTMAPK1 | |
| SCHEMBL8379055 | 0.85 | NR1H4 (0.58) | SMN1; SMN2EPHX2NR1H4MAPTMAPK1 | |
| SCHEMBL8382674 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8382680 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH2HRH1EPHX2NR1H4 | |
| SCHEMBL8383159 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2EPHX2NR1H4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |