SCHEMBL8380295

SCHEMBL8380295

C/C=C/C1CCC(c2ccc(-c3ccc(Cl)c(Cl)c3)nc2)CC1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
S1PR3 Q99500 2/20 0.38
KDM1A O60341 11/20 0.36
MAOB P27338 5/20 0.36
SLC6A3 Q01959 3/20 0.33
KMO O15229 1/20 0.33
S1PR1 P21453 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8380292 1.00 S1PR3 (0.38) S1PR3KDM1AMAOBSLC6A3KMO
SCHEMBL8381567 0.90 KDM1A (0.38) S1PR3KDM1AMAOBKMO
SCHEMBL9313264 0.90 KDM1A (0.38) S1PR3KDM1AMAOBKMO
SCHEMBL8381570 0.90 KDM1A (0.38) S1PR3KDM1AMAOBKMO
SCHEMBL9313268 0.90 KDM1A (0.38) S1PR3KDM1AMAOBKMO
SCHEMBL9313132 0.90 GRM2 (0.41) S1PR3KDM1AMAOBKMOS1PR1
SCHEMBL9313138 0.90 GRM2 (0.41) S1PR3KDM1AMAOBKMOS1PR1
SCHEMBL9313123 0.90 GRM2 (0.41) S1PR3KDM1AMAOBKMOS1PR1
SCHEMBL9313128 0.90 GRM2 (0.41) S1PR3KDM1AMAOBKMOS1PR1
SCHEMBL9311828 0.86 KDM1A (0.50) KDM1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0475273-B1 Liquid crystal mixture containing halogenated alcenyl compounds MERCK PATENT GMBH (DE) 1999-04-07 EP disclosed
EP-0475273-A1 Halogenated alcenyl compounds F. HOFFMANN-LA ROCHE AG (CH) 1992-03-18 EP disclosed