Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.74 |
| ▸ | CTSG | P08311 | 8/20 | 0.74 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8382640 | 0.85 | ELANE (0.78) | ELANECTSGFTOALDH1A1LMNA | |
| SCHEMBL8387055 | 0.85 | ELANE (0.71) | ELANECTSGFTOALDH1A1LMNA | |
| SCHEMBL29109693 | 0.85 | ELANE (0.68) | ELANECTSGFTOALDH1A1LMNA | |
| SCHEMBL8386350 | 0.81 | ELANE (0.71) | ELANECTSGFTOALDH1A1LMNA | |
| SCHEMBL8382534 | 0.80 | MEN1 (0.58) | ELANECTSGALDH1A1MAPTALOX15 | |
| SCHEMBL30293178 | 0.79 | ELANE (0.69) | ELANECTSGFTOALDH1A1LMNA | |
| SCHEMBL8386993 | 0.78 | MEN1 (0.55) | ELANECTSGALDH1A1MAPTALOX15 | |
| SCHEMBL8387182 | 0.77 | MAPT (0.54) | ELANECTSGALDH1A1MAPTALOX15 | |
| SCHEMBL30455815 | 0.77 | MEN1 (0.45) | ELANECTSGALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16795917 | 0.76 | IAPP (0.61) | SMN1; SMN2MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922891-A | ANTI-INFLAMMATORY AGENTS WHICH INHIBIT LIPOXYGENASE PATHWAYS AND THERFORE PROLIFERATIVE ACTIVITY OF PRODUCTS OF THE PATHWAYS; SUPPRESSION OF IRON-DEPENDENT GENERATION OF OXYGEN FREE RADICALS, TREATMENT OF PSORIASIS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1999-07-13 | — | — | US | disclosed |