Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380468 | 0.92 | CTSS (0.48) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL12844817 | 0.92 | CTSS (0.48) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7880435 | 0.91 | CTSS (0.57) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7872658 | 0.91 | CTSS (0.71) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7877564 | 0.89 | CTSS (0.51) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL13255009 | 0.88 | CTSS (0.62) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7868673 | 0.87 | CTSS (0.70) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7874012 | 0.87 | CTSS (0.68) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7873070 | 0.86 | CTSS (0.69) | CTSSADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL7879225 | 0.86 | CTSS (0.70) | CTSSADRB3ADRA2BADRA2CCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048862-B2 | Macrocyclic inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-10 | — | — | US | disclosed |
| US-20090269305-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269305-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | CTSS 659/4885ADRB3 4326/4885ADRA2B 4470/4885 |
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | CTSS 659/4885ADRB3 4326/4885ADRA2B 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.