Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8388494 | 0.97 | PTGS2 (0.66) | PTGS2PTGS1KCNH2MAP4K4PIK3CA | |
| SCHEMBL8387771 | 0.95 | PTGS2 (0.71) | PTGS2PTGS1KCNH2MAP4K4PIK3CA | |
| SCHEMBL8387850 | 0.88 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8652643 | 0.87 | PTGS2 (0.65) | PTGS2PTGS1KCNH2MAP4K4PIK3CA | |
| SCHEMBL8385280 | 0.86 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL8652520 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1KCNH2MAP4K4PIK3CA | |
| SCHEMBL8384836 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL8656452 | 0.85 | PTGS2 (0.69) | PTGS2PTGS1KCNH2MAP4K4PIK3CA | |
| SCHEMBL8386274 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL8385782 | 0.84 | PTGS2 (0.89) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5393790-A | Diphenyl- or phenyl/pyridyl-substituted spiroheptenes, -octenes,-nonenes or -decenes; cyclooxygenase II inhibitors; side effect reduction; antipyretics; antiarthritic agents | G.D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |