Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385184 | 0.98 | PTGS2 (0.61) | PTGS2PTGS1PDE10A | |
| SCHEMBL8386027 | 0.95 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8389072 | 0.89 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL8387187 | 0.87 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL8386204 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8386243 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8385354 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8387434 | 0.85 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8387478 | 0.84 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL8384032 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5393790-A | Diphenyl- or phenyl/pyridyl-substituted spiroheptenes, -octenes,-nonenes or -decenes; cyclooxygenase II inhibitors; side effect reduction; antipyretics; antiarthritic agents | G.D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |