Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.68 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.68 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387800 | 0.98 | CYP17A1 (0.70) | CYP17A1CYP11B1CYP11B2CYP3A4TP53 | |
| SCHEMBL15411832 | 0.86 | NOTUM (0.68) | CYP17A1CYP11B1CYP11B2CYP3A4NOTUM | |
| SCHEMBL27917353 | 0.85 | CYP17A1 (0.57) | CYP17A1CYP11B1CYP11B2CYP3A4TP53 | |
| SCHEMBL12452342 | 0.84 | NOTUM (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4NOTUM | |
| SCHEMBL12070468 | 0.84 | NOTUM (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4NOTUM | |
| SCHEMBL23729172 | 0.84 | NOTUM (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4NOTUM | |
| SCHEMBL14425853 | 0.84 | NOTUM (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4NOTUM | |
| SCHEMBL16605626 | 0.83 | TAAR1 (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4TAAR1 | |
| SCHEMBL16605628 | 0.83 | TAAR1 (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4TAAR1 | |
| SCHEMBL29628985 | 0.83 | TAAR1 (0.65) | CYP17A1CYP11B1CYP11B2CYP3A4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7452885-B2 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation | WYETH (US) | 2008-11-18 | — | — | US | disclosed |
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | BACE1, BACE2, APP | CYP17A1 883/4885CYP11B1 1665/4885CYP11B2 2183/4885 |
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | BACE1, BACE2, APP | CYP17A1 883/4885CYP11B1 1665/4885CYP11B2 2183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.