Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8390940 | 0.89 | S1PR3 (0.52) | S1PR3HDAC6HDAC3P2RX4PSEN1 | |
| SCHEMBL8389008 | 0.89 | S1PR3 (0.47) | S1PR3HDAC6HDAC3PSEN1PSEN2 | |
| SCHEMBL8391192 | 0.88 | S1PR3 (0.49) | S1PR3HDAC6HDAC3P2RX4PSEN1 | |
| SCHEMBL8390497 | 0.81 | NPSR1 (0.50) | S1PR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8388466 | 0.80 | KMT2A (0.55) | S1PR3P2RX4PSEN1PSEN2APH1B | |
| SCHEMBL9056373 | 0.79 | ELANE (0.57) | S1PR3P2RX4PSEN1PSEN2APH1B | |
| SCHEMBL8387151 | 0.79 | MAPT (0.65) | HDAC6HDAC3P2RX4PSEN1PSEN2 | |
| SCHEMBL8389101 | 0.77 | DYRK1A (0.52) | S1PR3P2RX4PSEN1PSEN2APH1B | |
| SCHEMBL8389023 | 0.77 | CYP3A4 (0.49) | S1PR3P2RX4PSEN1PSEN2APH1B | |
| SCHEMBL18382517 | 0.76 | CYP19A1 (0.70) | HDAC6HDAC3P2RX4HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877199-A | ALZHEIMER'S DISEASE; SEDATIVE | SANKYO COMPANY, LIMITED (JP) | 1999-03-02 | — | — | US | disclosed |
| CN-1166169-A | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors | SANKYO CO (JP) | 1997-11-26 | — | — | CN | disclosed |