Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389013 | 0.90 | MAPT (0.61) | MAPTHPGDTSHRHDAC6HDAC3 | |
| SCHEMBL1003148 | 0.87 | HDAC6 (0.67) | MAPTHPGDTSHRHDAC6HDAC3 | |
| SCHEMBL8390943 | 0.87 | MAPT (0.58) | MAPTHPGDTSHRHDAC6HDAC3 | |
| SCHEMBL8391190 | 0.85 | KDM4E (0.60) | MAPTHPGDTSHRHDAC6HDAC3 | |
| SCHEMBL8390500 | 0.82 | MAPT (0.58) | MAPTHPGDTSHRHDAC6HDAC1 | |
| SCHEMBL8388468 | 0.81 | MAPT (0.57) | MAPTHPGDTSHRALDH1A1P2RX4 | |
| SCHEMBL14199635 | 0.81 | P2RX4 (0.66) | MAPTHPGDTSHRHDAC6HDAC3 | |
| SCHEMBL14825105 | 0.79 | HPGD (1.00) | MAPTHPGDTSHRALDH1A1GAA | |
| SCHEMBL8387147 | 0.79 | S1PR3 (0.51) | MAPTHDAC6HDAC3HDAC1HDAC10 | |
| SCHEMBL18382517 | 0.78 | CYP19A1 (0.70) | MAPTHDAC6HDAC3HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877199-A | ALZHEIMER'S DISEASE; SEDATIVE | SANKYO COMPANY, LIMITED (JP) | 1999-03-02 | — | — | US | disclosed |
| CN-1166169-A | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors | SANKYO CO (JP) | 1997-11-26 | — | — | CN | disclosed |