Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | EYA2 | O00167 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324391 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7327670 | 0.90 | MEN1 (0.47) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL5243002 | 0.90 | MEN1 (0.47) | MEN1KMT2AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7333956 | 0.88 | MEN1 (0.46) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9233386 | 0.86 | MEN1 (0.33) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13180378 | 0.86 | PIK3CD (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL641812 | 0.85 | TDP1 (0.39) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL11186742 | 0.85 | TDP1 (0.39) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL18829310 | 0.83 | DRD3 (0.40) | ALDH1A1TDP1EYA2APPACE | |
| SCHEMBL10824154 | 0.81 | TDP1 (0.36) | TDP1EYA2APPACEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-1053893-C | Process for the manufacture of dicarboxamides | HOFFMANN LA ROCHE (CH) | 2000-06-28 | — | — | CN | disclosed |
| US-5856505-A | Intermediates for the manufacture of dicarboxamides having thrombin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5536867-A | Process for the manufacture of dicarboxamides | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | disclosed |
| CN-1117488-A | Process for the manufacture of dicarboxamides | HOFFMANN LA ROCHE (CH) | 1996-02-28 | — | — | CN | disclosed |
| EP-0684238-A2 | Process for the manufacture of dicarboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-29 | — | — | EP | disclosed |