Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878738 | 0.87 | TNIK (0.55) | TNIKAAK1BTKCYP2C9CYP2C19 | |
| SCHEMBL298800 | 0.86 | TNIK (0.54) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL3706659 | 0.86 | INSR (0.55) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL413564 | 0.86 | TNIK (0.52) | TNIKAAK1CYP2C9CYP2C19PIK3CA | |
| SCHEMBL409688 | 0.84 | TNIK (0.53) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL878650 | 0.84 | TNIK (0.54) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL415504 | 0.83 | TNIK (0.52) | TNIKAAK1CYP2C9CYP2C19PIK3CA | |
| SCHEMBL414867 | 0.83 | TNIK (0.53) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL857599 | 0.83 | BRAF (0.54) | TNIKAAK1BTKITKCYP2C9 | |
| SCHEMBL416872 | 0.82 | TNIK (0.56) | TNIKAAK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | TNIK 218/4885AAK1 120/4885BTK 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.