Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 17/20 | 0.97 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8388976 | 1.00 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL34471322 | 0.90 | INSR (0.80) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8388691 | 0.86 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8388688 | 0.86 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8386563 | 0.85 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8386565 | 0.85 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| SCHEMBL14434821 | 0.85 | INSR (1.00) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8387880 | 0.83 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| Iodide SCHEMBL8387879 | 0.83 | INSR (0.97) | INSRNSD2POLBMAPTMAPK1 | |
| SCHEMBL14984211 | 0.81 | INSR (1.00) | INSRNSD2POLBMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | claimed |
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | disclosed |
| WO-1997026919-A2 | METHOD OF IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1997-07-31 | — | — | WO | disclosed |