Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338613 | 0.89 | POLB (0.31) | POLBSMN1; SMN2 | |
| SCHEMBL8333747 | 0.87 | POLB (0.41) | POLBSMN1; SMN2 | |
| SCHEMBL8336129 | 0.77 | ALDH1A1 (0.40) | SMN1; SMN2 | |
| SCHEMBL8336503 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2 | |
| SCHEMBL8340670 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2 | |
| SCHEMBL8339740 | 0.75 | ALDH1A1 (0.39) | POLB | |
| SCHEMBL8336354 | 0.70 | KMT2A (0.36) | POLBSMN1; SMN2 | |
| SCHEMBL8339788 | 0.69 | POLB (0.36) | POLBSMN1; SMN2 | |
| SCHEMBL8337751 | 0.67 | CYP3A4 (0.38) | — | |
| SCHEMBL169872 | 0.63 | KMT2A (0.47) | POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |