SCHEMBL8390608

SCHEMBL8390608

CC(=NOCCOc1ccc(CC2SC(=O)NC2=O)cc1)c1cn(C)c(-c2ccccc2)n1

nearest known ligand 0.66

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 12/20 0.66
FFAR1 O14842 9/20 0.50
HRH3 Q9Y5N1 1/20 0.46
PPARA Q07869 2/20 0.46
RARG P13631 1/20 0.44
RXRA P19793 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8390605 1.00 PPARG (0.66) PPARGFFAR1HRH3PPARARARG
SCHEMBL8309643 0.83 PPARG (0.71) PPARGFFAR1RARGRXRA
SCHEMBL8309644 0.83 PPARG (0.71) PPARGFFAR1RARGRXRA
SCHEMBL8305218 0.83 PPARG (0.46) PPARGFFAR1PPARARARGRXRA
SCHEMBL8305220 0.83 PPARG (0.46) PPARGFFAR1PPARARARGRXRA
SCHEMBL8304604 0.83 PPARG (0.66) PPARGFFAR1RARGRXRA
SCHEMBL6898656 0.82 PPARG (0.81) PPARGFFAR1
SCHEMBL6899309 0.82 PPARG (0.81) PPARGFFAR1
SCHEMBL8309657 0.82 PPARG (0.76) PPARGFFAR1PPARA
SCHEMBL8309658 0.82 PPARG (0.76) PPARGFFAR1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972959-A Oxime derivatives, their preparation and their therapeutic use SANKYO COMPANY, LIMITED (JP) 1999-10-26 US disclosed