Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 17/20 | 0.98 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8390913 | 1.00 | INSR (0.98) | INSRPOLBMAPTNPSR1NSD2 | |
| SCHEMBL34467576 | 0.99 | INSR (1.00) | INSRPOLBMAPTNPSR1NSD2 | |
| SCHEMBL14984268 | 0.86 | INSR (0.82) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL8387888 | 0.84 | INSR (0.97) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL8387885 | 0.84 | INSR (0.97) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL8390122 | 0.83 | INSR (0.72) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL8390125 | 0.83 | INSR (0.72) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL34471322 | 0.83 | INSR (0.80) | INSRPOLBMAPTNPSR1NSD2 | |
| SCHEMBL12301991 | 0.81 | INSR (0.69) | INSRPOLBMAPTNPSR1NSD2 | |
| Iodide SCHEMBL8387880 | 0.81 | INSR (0.97) | INSRPOLBMAPTNPSR1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | claimed |
| WO-1997026919-A2 | METHOD OF IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1997-07-31 | — | — | WO | claimed |
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | disclosed |
| WO-1997026919-A2 | METHOD OF IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1997-07-31 | — | — | WO | disclosed |