Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838930 | 0.84 | — | — | |
| SCHEMBL17548166 | 0.74 | KDM4E (0.34) | KDM4ELMNACYP2C19 | |
| SCHEMBL15116226 | 0.63 | — | — | |
| SCHEMBL8903859 | 0.63 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL8902159 | 0.63 | ALDH1A1 (0.36) | LMNAALDH1A1 | |
| SCHEMBL761687 | 0.63 | MEN1 (0.39) | KDM4EALDH1A1CYP19A1 | |
| SCHEMBL13686223 | 0.62 | KDM4E (0.54) | KDM4ELMNACYP2C19CHRM2CHRM3 | |
| SCHEMBL8903780 | 0.62 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL2712615 | 0.61 | CRBN (0.35) | — | |
| SCHEMBL21151722 | 0.60 | GRM5 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143241-B2 | DNA damage repair inhibitors for treatment of cancer | KUDOS PHARMACEUTICALS LIMITED (GB) | 2012-03-27 | — | — | US | disclosed |
| US-7196085-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |