Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.68 |
| ▸ | CCR4 | P51679 | 5/20 | 0.56 |
| ▸ | EDNRB | P24530 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042542 | 0.85 | EDNRA (0.75) | EDNRA | |
| SCHEMBL8394999 | 0.84 | EDNRA (0.73) | EDNRACCR4EDNRBHCRTR1 | |
| SCHEMBL8392301 | 0.84 | EDNRA (0.72) | EDNRACCR4EDNRBHCRTR1 | |
| SCHEMBL8395583 | 0.83 | EDNRA (0.74) | EDNRACCR4EDNRBHCRTR1 | |
| SCHEMBL8391602 | 0.82 | EDNRA (0.69) | EDNRACCR4EDNRB | |
| SCHEMBL8042519 | 0.81 | EDNRA (1.00) | EDNRACCR4 | |
| SCHEMBL8395498 | 0.80 | EDNRA (0.98) | EDNRACCR4 | |
| SCHEMBL8395496 | 0.80 | EDNRA (0.98) | EDNRACCR4 | |
| SCHEMBL8391561 | 0.79 | EDNRA (0.79) | EDNRACCR4 | |
| SCHEMBL8391589 | 0.77 | EDNRA (0.62) | EDNRACCR4EDNRBHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752986-B1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LTD (GB) | 1999-05-19 | — | — | EP | disclosed |