⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38083 | 0.77 | — | — | |
| SCHEMBL68517 | 0.75 | — | — | |
| SCHEMBL2369945 | 0.73 | — | — | |
| SCHEMBL16952831 | 0.72 | — | — | |
| SCHEMBL12097246 | 0.72 | — | — | |
| SCHEMBL9131545 | 0.72 | — | — | |
| SCHEMBL7543636 | 0.72 | — | — | |
| SCHEMBL16955027 | 0.72 | — | — | |
| SCHEMBL16955271 | 0.72 | — | — | |
| SCHEMBL11192120 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158354-A1 | Process for Preparing 2-[[5-(3-Chlorophenyl)-3-Hydroxypyridine-2-Carbonyl]Amino]Acetic Acid | KREOS CAPITAL VII (UK) LIMITED (GB) | 2024-05-16 | — | — | US | disclosed |
| US-11713298-B2 | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid | AKEBIA THERAPEUTICS, INC. (US) | 2023-08-01 | — | — | US | disclosed |
| EP-3131897-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2022-06-15 | — | — | EP | disclosed |
| CN-110382609-B | Studless tire | 住友橡胶工业株式会社 | 2022-03-22 | — | — | CN | disclosed |
| EP-3790863-A1 | PROCESS FOR PREPARING 2-[[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO]ACETIC ACID | Akebia Therapeutics Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| US-20210070709-A1 | Process for Preparing 2-[[5-(3-Chlorophenyl)-3-Hydroxypyridine-2-Carbonyl]Amino]Acetic Acid | KREOS CAPITAL VII (UK) LIMITED (GB) | 2021-03-11 | — | — | US | disclosed |
| CN-112088155-A | Process for the preparation of 2- [ [5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl ] amino ] acetic acid | 阿克比治疗有限公司 | 2020-12-15 | — | — | CN | disclosed |
| CN-107531819-B | Catalyst composition for preparing conjugated diene-based polymer and conjugated diene-based polymer prepared using the same | LG化学株式会社 | 2020-05-12 | — | — | CN | disclosed |
| CN-107531820-B | Catalyst composition for preparing conjugated diene-based polymer and conjugated diene-based polymer prepared using the same | LG化学株式会社 | 2020-05-12 | — | — | CN | disclosed |
| WO-2019217550-A1 | PROCESS FOR PREPARING 2-[[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO]ACETIC ACID | AKEBIA THERAPEUTICS, INC. (US) | 2019-11-14 | — | — | WO | disclosed |
| US-7378522-B2 | Such as 6-(4-Acetamidophenoxy)-5-(N-benzyl-N-methylaminomethyl)-1-(2',6'-difluorobenzyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid-ethyl ester; rapid effectiveness, bioavailability; low cost, simple synthesis | ZENTARIS AG (DE) | 2008-05-27 | — | — | US | disclosed |
| US-20080038785-A1 | Processes For Preparing Optically Active (S Or R-)-Beta-Amino Acid And Optically Active (R Or S)-Beta-Amino Acid Ester, And Beta-Amino Acid 2-Alkoxyethyl Ester And Optically Active (S Or R)-Beta Amino Acid 2-Alkoxyethyl Ester | UBE INDUSTRIES, LTD. (JP) | 2008-02-14 | — | — | US | disclosed |
| EP-1887086-A1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID USING SURFACTANT-MODIFYING ENZYME | Ube Industries, Ltd. (JP) | 2008-02-13 | — | — | EP | disclosed |
| EP-1840218-A1 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE (S)- OR (R)- BETA-AMINO ACIDS AND OPTICALLY ACTIVE (R)- OR (S)-BETA -AMINO ACID ESTERS, 2-ALKOXYETHYL ESTERS OF -AMINO ACIDS, AND OPTICALLY ACITVE (S)- OR (R)-2-ALKOXYETHYL ESTERS OF -AMINO ACIDS | Ube Industries, Ltd. (JP) | 2007-10-03 | — | — | EP | disclosed |
| US-20050170473-A1 | Process for producing either optically active n-substituted beta-amino acid and optically active n-substituted beta-amino acid ester or optically active n-substituted 2-homopipecolic acid and optically active n-substituted 2-homopipecolic acid ester | UBE INDUSTRIES, LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
| US-20050004127-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | AETERNA ZENTARIS GMBH (DE) | 2005-01-06 | — | — | US | disclosed |
| EP-1493819-A1 | PROCESS FOR PRODUCING EITHER OPTICALLY ACTIVE N-SUBSTITUTED BETA-AMINO ACID AND OPTICALLY ACTIVE N-SUBSTITUTED BETA-AMINO ACID ESTER OR OPTICALLY ACTIVE N-SUBSTITUTED 2-HOMOPIPECOLIC ACID AND OPTICALLY ACTIVE N-SUBSTITUTED 2-HOMOPIPECOLIC ACID ESTER | Ube Industries, Ltd. (JP) | 2005-01-05 | — | — | EP | disclosed |
| US-6790858-B2 | HIGH EFFECTIVENESS AND HIGH ORAL BIOAVAILABILITY; FOR EXAMPLE, 6-(4-ACETAMIDOPHENYL)-3-ISOBUTYRYL-5-(N-BENZYL-N-METHYLAMINOMETHYL)-1-(2',6'-DIFLUOROBENZYL)-1,4-DIHYDRO-4-OXOQUINOLINE | ZENTARIS AG (DE) | 2004-09-14 | — | — | US | disclosed |
| US-20030105328-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | SCHERING AG (DE) | 2003-06-05 | — | — | US | disclosed |
| US-4285961-A | MICROBIOCIDES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-08-25 | — | — | US | disclosed |