Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8392397 | 0.99 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8393077 | 0.94 | POLB (0.47) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| Bromide SCHEMBL8394207 | 0.93 | POLB (0.46) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8392823 | 0.83 | RAB9A (0.50) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8394219 | 0.82 | NAMPT (0.57) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8481529 | 0.78 | HTT (0.59) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8391973 | 0.78 | POLB (0.57) | NPC1RAB9AALOX15POLBNAAA | |
| SCHEMBL8396579 | 0.78 | POLB (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL8392843 | 0.77 | MAPT (0.62) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| Bromide SCHEMBL8397243 | 0.76 | MAPT (0.60) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |